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Solving the protein folding problem…
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DOI：10.1002/1873-3468.15043.png)
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摘要
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The protein folding problem was, to paraphrase Churchill, 'A riddle wrapped in a mystery inside an enigma'. The riddle, in this context, was the folding code; what interactions at the amino acid level are driving the folding process? The mystery was the kinetic question (Levinthal's paradox); how does the folding process occur so quickly (typically in timescales ranging from mu S to mS)? Finally, the enigma represents the computational problem of developing approaches to predict the final folded sate of a protein given only its amino acid sequence. Herein, I trace the path to solving this riddle wrapped in a mystery inside an enigma.
Keyword:
AlphaFold
ESMFold
folding funnel hypothesis
Folding@Home
Foldit
RoseTTAFold
zipping and assembly
期刊
IF:
3
论文数:
2.3W
被引数:
3.8W
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