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SpaGIC: graph-informed clustering in spatial transcriptomics via self-supervised contrastive learning
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DOI：10.1093/bib/bbae578.png)
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Spatial transcriptomics technologies enable the generation of gene expression profiles while preserving spatial context, providing the potential for in-depth understanding of spatial-specific tissue heterogeneity. Leveraging gene and spatial data effectively is fundamental to accurately identifying spatial domains in spatial transcriptomics analysis. However, many existing methods have not yet fully exploited the local neighborhood details within spatial information. To address this issue, we introduce SpaGIC, a novel graph- based deep learning framework integrating graph convolutional networks and self-supervised contrastive learning techniques. SpaGIC learns meaningful latent embeddings of spots by maximizing both edge-wise and local neighborhood-wise mutual information of graph structures, as well as minimizing the embedding distance between spatially adjacent spots. We evaluated SpaGIC on seven spatial transcriptomics datasets across various technology platforms. The experimental results demonstrated that SpaGIC consistently outperformed existing state-of-the-art methods in several tasks, such as spatial domain identification, data denoising, visualization, and trajectory inference. Additionally, SpaGIC is capable of performing joint analyses of multiple slices, further underscoring its versatility and effectiveness in spatial transcriptomics research.
Keyword:
spatial transcriptomics
spatial domain identification
graph convolutional networks
self-supervised contrastive learning
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