.png){kind=icon}
返回
Spatial Single-cell Technologies for Exploring Gastrointestinal Tissue Transcriptome
.png){kind=icon}
PRE
AI
DOI：10.1002/cphy.c210053.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
In the gastrointestinal (GI) system, like in other organ systems, the histological structure is a key determinant of physiological function. Tissues form multiple layers in the GI tract to perform their specialized functions in secretion, absorption, and motility. Even at the single layer, the heterogeneous cell population performs a diverse range of digestive or regulatory functions. Although many details of such functions at the histological and cell biological levels were revealed by traditional methods such as cell sorting, isolation, and culture, as well as histological methods such as immunostaining and RNA in situ hybridization, recent advances in spatial single-cell technologies could further contribute to our understanding of the molecular makeup of GI histological structures by providing a genome-wide overview of how different genes are expressed across individual cells and tissue layers. The current minireview summarizes recent advances in the spatial transcriptomics field and discusses how such technologies can promote our understanding of GI physiology.& COPY; 2023 American Physiological Society. Compr Physiol 13:4709-4718, 2023.
Keyword:
GENOME-WIDE EXPRESSION
GENE-EXPRESSION
RNA-SEQ
RECONSTRUCTION
PROTEINS
ATLAS
期刊
IF:
5.2
论文数:
953
被引数:
8.4K
机构
引用论文
Hybridization-based in situ sequencing (HybISS) for spatially resolved transcriptomics in human and mouse brain tissue基于杂交的原位测序 (HybISS) 用于人和小鼠脑组织中的空间分辨转录组学.png)
NUCLEIC ACIDS RESEARCH
OAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Spatial transcriptomics atlas reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment components in colorectal cancer空间转录组图谱揭示了结直肠癌中癌症相关成纤维细胞与肿瘤微环境成分之间的串扰OAAI
OAAI分享收藏High-throughput spatial mapping of single-cell RNA-seq data to tissue of origin单细胞rna-seq数据到原始组织的高通量空间映射NATURE BIOTECHNOLOGYOAAI
NATURE BIOTECHNOLOGYIF41.7
OAAI分享收藏Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis空间和单细胞转录组数据的整合阐明了小鼠器官发生NATURE BIOTECHNOLOGYOAAI
NATURE BIOTECHNOLOGYIF41.7
OAAI分享收藏
查看更多内容