Stem cell regulation by polycomb repressors: postponing commitment

doi:10.1016/j.ceb.2008.01.004

2008-04-01

255

PRE

Alexandra M Pietersen *

Maarten van Lohuizen

DOI：10.1016/j.ceb.2008.01.004

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摘要

En 中文

Polycomb group proteins (PcGs) are involved in gene repression through chromatin modifications and required for the maintenance of both embryonic and adult stem cells. Genome-wide studies demonstrate that genes targeted by PcG are predominantly developmental transcription factors. In embryonic stem cells, these genes carry not only a repressive PcG mark but also an activating mark, resulting in so-called 'bivalent domains'. New data suggest that genes with bivalent domains are primed for differential expression upon differentiation. We propose that the resolution of a bivalent domain into either an active or repressed state constitutes a cell fate decision, and that by postponing these decisions PcG contributes to pluripotency.

Keyword:

SELF-RENEWAL

HISTONE H3

DEVELOPMENTAL REGULATORS

EPIGENETIC REGULATION

GENE-EXPRESSION

TARGET GENES

BMI-1

DEMETHYLATION

INFLAMMATION

PLURIPOTENT

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期刊

Current Opinion in Cell Biology

IF:

4.3

论文数:

3.2K

被引数:

1.2W

机构

Netherlands Cancer Institute

学者数:

10.0K

论文数: 7.4K

被引数: 1.3W

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