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Streamlining enzyme discovery and development through data analysis and computation
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DOI：10.1016/j.checat.2025.101445.png)
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摘要
En 中文
• 开发基于Python的高分辨率LC-MS分析流程
• 基于数据的发现先前未知的酶促反应产物
• 鉴定出一种能够去甲基化soraphen A的WelO5∗变体
• 生物信息学促进WelO5∗的快速优化，提升3倍
Keyword:
biocatalysis
non-heme Fe(II)/α-ketoglutarate-dependent dioxygenases
LC-MS data analysis
oxidative demethylation
computational enzyme design
late-stage functionalization
biotransformation
soraphen A
SDG3: Good health and well-being
SDG9: Industry, innovation, and infrastructure
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期刊
IF:
11.6
论文数:
1.3K
被引数:
5.6K
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