.png){kind=icon}
返回
Structure-function of type I and III interferons
.png){kind=icon}
PRE
AI
DOI：10.1016/j.coi.2024.102413.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Type I and type III interferons (IFNs) are major components in activating the innate immune response. Common to both are two distinct receptor chains (IFNAR1/IFNAR2 and IFNLR1/ IL10R2), which form ternary complexes upon binding their respective ligands. This results in close proximity of the intracellularly associated kinases JAK1 and TYK2, which cross phosphorylate each other, the associated receptor chains, and signal transducer and activator of transcriptions, with the latter activating IFN-stimulated genes. While there are clear similarities in the biological responses toward type I and type III IFNs, differences have been found in their tropism, tuning of activity, and induction of the immune response. Here, we focus on how these differences are embedded in the structure/function relations of these two systems in light of the recent progress that provides in-depth information on the structural assembly of these receptors and their functional implications and how these differ between the mouse and human systems.
Keyword:
RECEPTOR ACTIVATION
COMPLEX REVEALS
ALPHA RECEPTOR
STAT2
EXPRESSION
MECHANISM
AFFINITY
DISTINCT
SUBUNIT
DIMERIZATION
期刊
IF:
5.8
论文数:
3.4K
被引数:
9.5K
机构
引用论文
分享收藏分享收藏De novo developed protein binders mimicking Interferon lambda signalingDe novo开发了模拟干扰素 λ 信号的蛋白质结合剂.png)
FEBS JOURNAL
FEBS JOURNALIF4.2
PREAI
分享收藏Dynamic Expression Profiling of Type I and Type III Interferon-Stimulated Hepatocytes Reveals a Stable Hierarchy of Gene ExpressionHEPATOLOGY
OAAI
HEPATOLOGYIF15.8
OAAI分享收藏
查看更多内容