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Structured Synaptic Connectivity between Hippocampal Regions
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DOI：10.1016/j.neuron.2013.11.026.png)
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The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
Keyword:
CA1 PYRAMIDAL NEURONS
IN-VIVO
CORTICAL-NEURONS
RAT
DENDRITES
CELLS
INTEGRATION
MULTIPLE
INPUTS
ORGANIZATION
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15
论文数:
1.4W
被引数:
9.9W
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