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Subcellular mRNA localization patterns across tissues resolved with spatial transcriptomics

delete2026-04-20
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OA
AI
R
Roy Novoselsky
O
Ofra Golani
T
Tal Barkai
M
Merav Kedmi
I
Inna Goliand
M
Michal Fine
I
Ilan Kent
I
Ido Nachmany
S
Shalev Itzkovitz *
DOI：10.1038/s41467-026-72156-7delete
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摘要

摘要

En 中文
亚细胞RNA定位，包括核保留和极性上皮细胞的顶-基底隔室化，在转录后调控中发挥核心作用。然而，针对完整组织切片中mRNA定位的高通量绘制方法仍有限。本研究应用高分辨率空间转录组学，系统解析了不同哺乳动物组织中的细胞内mRNA定位。我们引入了一种计算方法，利用图像衍生特征从空间数据中提取亚细胞信息并量化转录定位模式。利用该框架，我们绘制了胃肠道上皮和肝细胞的顶-基底mRNA定位及核保留。我们的分析揭示了保守的和组织特异性的定位特征。该方法通过实现对健康和疾病组织中细胞内RNA分布的常规研究，扩展了空间转录组学的应用范围。亚细胞RNA定位在转录后调控中发挥核心作用。通过高分辨率空间转录组学和计算方法，本研究绘制了组织中的细胞内mRNA定位，揭示了保守的定位模式，并实现了对细胞中RNA分布的常规分析。
Keyword:
Apicobasal polarity
Computational biology and bioinformatics
RNA transport
Systems biology
Science
Humanities and Social Sciences
multidisciplinary
AI总结

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对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Nature Communications 封面图
Nature Communications
IF:
15.7
论文数:
9.3W
被引数:
91.2W

机构

W
Weizmann Institute of Science
学者数:
1.3W
论文数: 1.1W
被引数: 2.3W
T
Tel Aviv University
学者数:
3.7W
论文数: 3.0W
被引数: 3.6W
引用论文

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