logo
科言猫学术研究的AI总结
language
手机端手机端
  • Phone Feature微信小程序
简体中文简体中文
notice消息通知
博客博客
delete
arrow
返回

Tear fluid database: a reference website for tear fluid proteomics

delete2026-01-01
delete0
PRE
AI
D
Drew Mayernik
S
Saleh Ahmed
E
Eliza Williams
T
Tae Jin Lee
A
Amy Estes
P
Pamela M. Martin
W
Wenbo Zhi
J
Jhanji, Vishal
S
Shruti Sharma
A
Ashok Sharma *
DOI：10.1093/database/baaf091delete
delete原文链接
delete原文求助
delete分享
delete收藏
摘要

摘要

En 中文
泪液是一种临床可获取、微创的生物体液，具有复杂且动态变化的蛋白质组。泪液成分的分子改变已被与广泛的眼睛和全身性疾病相关联；然而，泪液样本体积小给获取高质量蛋白质组数据带来了巨大挑战。为克服这一限制，我们开发了一种高灵敏度质谱工作流程，能够从单个泪液样本中鉴定出超过1,000种蛋白质。将该工作流程应用于大型且多样化的队列，我们生成了代表性且全面的人类泪液蛋白质组谱，并建立了泪液中常见检测蛋白质的参考丰度范围。在蛋白质定量分析的同时，我们收集了每位参与者的详细临床注释。随着数据库的持续增长，这些分析将越来越多地支持识别与疾病相关的蛋白质组特征，加深我们对潜在生物学机制的理解，并加速临床相关生物标志物的发现。为使这些数据广泛可用，我们创建了一个用户友好的网站，用于探索蛋白质测量结果及其相关的临床元数据。当前版本包括74份人类泪液样本的蛋白质组谱，涵盖2,134种独特蛋白质。泪液数据库作为生物标志物发现、比较蛋白质组学和泪液生物学系统水平研究的基础资源，为科学界提供了一个强大且可扩展的平台，以推动泪液蛋白质组学研究。数据库网址：https://tearfluid.org/
Keyword:
BIOMARKERS
FILM
LACTOFERRIN

期刊

D
Database-The Journal of Biological Databases and Curation
IF:
3.6
论文数:
1.8K
被引数:
6.1K

机构

U
university system of georgia
学者数:
7.3W
论文数: 6.6W
被引数: 101
A
augusta university
学者数:
702
论文数: 334
被引数: 0
引用论文

引用论文

Biochemistry of human tear film: A review人类泪膜的生物化学: 综述
errEXPERIMENTAL EYE RESEARCH
IF2.7
err2022-07-01
err41
PREAI
errMasoudi, Simin
err分享
err收藏
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughputDia-nn: 神经网络和干扰校正可实现高通量的深度蛋白质组覆盖
errNATURE METHODS
IF32.1
err2019-11-25
err983
errOAAI
errDemichev, Vadim; Messner, Christoph B.; Vernardis, Spyros I.; Lilley, Kathryn S.; Ralser, Markus
err分享
err收藏
Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles
errJOURNAL OF MATERIALS CHEMISTRY B
IF5.7
err2014-01-01
err48
errOAAI
errWang, Wan; Despanie, Jordan; Shi, Pu; Edman, Maria C.; Lin, Yi-An; Cui, Honggang; Heur, Martin; Fini, M. Elizabeth; Hamm-Alvarez, Sarah F.; MacKay, J. Andrew
err分享
err收藏
Biochemical-molecular-genetic biomarkers in the tear film, aqueous humor, and blood of primary open-angle glaucoma patients原发性开角型青光眼患者泪膜，房水和血液中的生化分子遗传生物标志物
errFRONTIERS IN MEDICINE
IF3
err2023-05-26
err9
errOAAI
errPinazo-Duran, Maria D.; Zanon-Moreno, Vicente; Garcia-Villanueva, Carolina; Martucci, Alessio; Peris-Martinez, Cristina; Vila-Arteaga, Jorge; Garcia-Medina, Jose J.; Andres-Blasco, Irene; Gallego-Martinez, Alex; Nucci, Carlo; Garcia-Feijoo, Julian
err分享
err收藏
Growth factors in the tear film: Role in tissue maintenance, wound healing, and ocular pathology
errOCULAR SURFACE
IF5.6
err2007-07-01
err108
PREAI
errKlenkler, Bettina; Sheardown, Heather; Jones, Lyndon
err分享
err收藏
The power of tears: how tear proteomics research could revolutionize the clinic眼泪的力量: 眼泪蛋白质组学研究如何彻底改变临床
errEXPERT REVIEW OF PROTEOMICS
IF2.8
err2017-02-01
err62
errOAAI
errZhou, Lei; Beuerman, Roger W.
err分享
err收藏
TFOS DEWS II Tear Film ReportTFOS DEWS II催泪膜报告
errOCULAR SURFACE
IF5.6
err2017-07-01
err657
errOAAI
errWillcox, Mark D. P.; Argueso, Pablo; Georgiev, Georgi A.; Holopainen, Juha M.; Laurie, Gordon W.; Millar, Tom J.; Papas, Eric B.; Rolland, Jannick P.; Schmidt, Tannin A.; Stahl, Ulrike; Suarez, Tatiana; Subbaraman, Lakshman N.; Ucakhan, Omur O.; Jones, Lyndon
err分享
err收藏
Tear Biomarkers and Alzheimer’s Disease
errInternational Journal of Molecular Sciences
IF0
err2023-08-30
err0
errOAAI
errSnježana Kaštelan; Marijana Braš; Neda Pjevač; Ivana Bakija; Zora Tomić; Nada Pjevač Keleminić; Antonela Gverović Antunica
err分享
err收藏
UniProt: the Universal Protein Knowledgebase in 2025UniProt: 通用蛋白质知识库2025年
errNucleic Acids Research
IF0
err2024-11-18
err0
errOAAI
errAlex Bateman; Maria-Jesus Martin; Sandra Orchard; Michele Magrane; Aduragbemi Adesina; Shadab Ahmad; Emily H Bowler-Barnett; Hema Bye-A-Jee; David Carpentier; Paul Denny; Jun Fan; Penelope Garmiri; Leonardo Jose da Costa Gonzales; Abdulrahman Hussein; Alexandr Ignatchenko; Giuseppe Insana; Rizwan Ishtiaq; Vishal Joshi; Dushyanth Jyothi; Swaathi Kandasaamy; Antonia Lock; Aurelien Luciani; Jie Luo; Yvonne Lussi; Juan Sebastian Martinez Marin; Pedro Raposo; Daniel L Rice; Rafael Santos; Elena Speretta; James Stephenson; Prabhat Totoo; Nidhi Tyagi; Nadya Urakova; Preethi Vasudev; Kate Warner; Supun Wijerathne; Conny Wing-Heng Yu; Rossana Zaru; Alan J Bridge; Lucila Aimo; Ghislaine Argoud-Puy; Andrea H Auchincloss; Kristian B Axelsen; Parit Bansal; Delphine Baratin; Teresa M Batista Neto; Marie-Claude Blatter; Jerven T Bolleman; Emmanuel Boutet; Lionel Breuza; Blanca Cabrera Gil; Cristina Casals-Casas; Kamal Chikh Echioukh; Elisabeth Coudert; Beatrice Cuche; Edouard de Castro; Anne Estreicher; Maria L Famiglietti; Marc Feuermann; Elisabeth Gasteiger; Pascale Gaudet; Sebastien Gehant; Vivienne Gerritsen; Arnaud Gos; Nadine Gruaz; Chantal Hulo; Nevila Hyka-Nouspikel; Florence Jungo; Arnaud Kerhornou; Philippe Le Mercier; Damien Lieberherr; Patrick Masson; Anne Morgat; Salvo Paesano; Ivo Pedruzzi; Sandrine Pilbout; Lucille Pourcel; Sylvain Poux; Monica Pozzato; Manuela Pruess; Nicole Redaschi; Catherine Rivoire; Christian J A Sigrist; Karin Sonesson; Shyamala Sundaram; Anastasia Sveshnikova; Cathy H Wu; Cecilia N Arighi; Chuming Chen; Yongxing Chen; Hongzhan Huang; Kati Laiho; Minna Lehvaslaiho; Peter McGarvey; Darren A Natale; Karen Ross; C R Vinayaka; Yuqi Wang; Jian Zhang
err分享
err收藏
Comparison of Different Mass Spectrometry Workflows for the Proteomic Analysis of Tear Fluid泪液蛋白质组学分析中不同质谱流程的比较
errInternational Journal of Molecular Sciences
IF0
err2022-02-19
err0
errOAAI
errGarrett Jones; Tae Jin Lee; Joshua Glass; Grace Rountree; Lane Ulrich; Amy Estes; Mary Sezer; Wenbo Zhi; Shruti Sharma; Ashok Sharma
err分享
err收藏
学者 查看更多内容