Temporal tissue dynamics from a spatial snapshot

Jonathan Somer

doi:10.1038/s41586-025-09876-1

2026-01-21

Jonathan Somer *

Shie Mannor *

Uri Alon *

DOI：10.1038/s41586-025-09876-1

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摘要

En 中文

随着时间的推移，细胞之间的相互作用会产生诸如炎症和癌症等生理和病理过程1。然而，缺乏在人类组织的天然背景下随时间追踪细胞群体的方法，因为活检仅提供单个快照。在这里，我们介绍了一次组织动力学重建 (OSDR)，这是一种基于单个组织样本估计细胞群动力学模型的方法。OSDR使用空间蛋白质组学来了解细胞邻域的组成如何影响分裂率，从而提供细胞群体随时间变化的动态模型。我们将OSDR应用于人乳腺癌data2-4，并重建了成纤维细胞和巨噬细胞相互作用的两个固定点5，6。这些固定点对应于热和冷的纤维化7，与直接测量这些动力学的共培养实验8一致。然后，我们使用OSDR发现肿瘤微环境中T和b细胞的脉冲产生可兴奋回路，表明抗癌免疫反应的时间耀斑。最后，我们研究了来自三阴性乳腺癌临床试验3的纵向活检，其中OSDR基于早期治疗活检预测了应答者中肿瘤细胞群的崩溃，而非非应答者。OSDR可以应用于广泛的空间蛋白质组学测定，以实现基于患者活检的组织动力学分析。一次性组织动力学重建可以从人类癌症的单个时间点空间蛋白质组学中推断组织组成随时间的变化。

Keyword:

cell population dynamics

spatial proteomics

tissue microenvironment

cancer immunology

dynamical modeling

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期刊

Nature

IF:

48.5

论文数:

1.8W

被引数:

96.5W

机构

weizmann institute of science

学者数:

411

论文数: 162

被引数: 0

technion israel institute of technology

学者数:

1.8K

论文数: 777

被引数: 0

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