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The development of anti-HIV agents targeting APOBEC3G/Vif axis

delete2025-12-11
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PRE
AI
Q
Qiqi Bao
J
Jiajia Wen
F
Fengjiao Xiang
L
Ling Ma
J
Jiwei Ding
X
Xinlu Wang
S
Shan Cen *
J
Jinming Zhou *
DOI：10.1016/j.bmc.2025.118519delete
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Abstract

Abstract

En 中文
• 64 analogs were designed and synthesized to optimize the anti-HIV-1 activities of previously reported compound IMB-301. • Several analogs exhibits significantly enhanced potency relative to IMB-301. • The active analogs block the Vif-A3G interaction, restore intracellular A3G levels, and ultimately inhibit HIV-1 proliferation in an A3G-dependent manner.

Journal

B
Bioorganic and Medicinal Chemistry
IF:
3
Papers:
1.7W
Citations:
2.7W

Organization

P
Peking Union Medical College
Scholars:
1.8W
Papers: 1.4W
Citations: 20
T
taizhou university
Scholars:
4.8K
Papers: 3.3K
Citations: 76
Z
Zhejiang Normal University
Scholars:
1.3W
Papers: 8.4K
Citations: 1.2W
C
chinese academy of sciences
Scholars:
54.9W
Papers: 44.5W
Citations: 703
Cited Papers

Cited Papers

Citing Papers

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