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The minimal chemotactic cell

delete2025-07-25
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OA
AI
B
Bárbara Borges-Fernandes
A
Azzurra Apriceno
A
A. Arango-Restrepo
S
Safa Almadhi
S
Subhadip Ghosh
J
Joe Forth
J
Jorge P. López‐Alonso
I
Iban Ubarretxena‐Belandia
J
J. M. Rubı́
L
Lorena Ruiz‐Pérez
I
Ian Williams
G
Giuseppe Battaglia *
DOI：10.1126/sciadv.adx9364delete
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摘要

摘要

En 中文
化学趋向性是指细胞和微生物对化学梯度的响应运动，是众多生物过程进化的基础。在本工作中，我们证明即使是简单的类细胞结构也具备化学趋向性导航能力。通过将酶封装在整合了最少膜孔的脂质体中，我们发现单个脂质体可以主动向酶底物梯度推进。具体而言，在受控底物梯度下，我们将装载葡萄糖氧化酶或尿素酶并嵌入相应跨膜蛋白的脂质体置于微流控装置中进行追踪。我们的发现表明，仅由封装的酶和单个跨膜孔组成的系统足以启动化学趋向性。这一概念验证模型强调了细胞导航机制简约而强大的本质，为生物系统中化学趋向性行为的起源和进化提供了全新的视角。
Keyword:
chemotaxis
lipid vesicles
enzyme encapsulation
transmembrane pores
microfluidic device
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期刊

Science Advances 封面图
Science Advances
IF:
12.5
论文数:
2.1W
被引数:
18.1W

机构

U
University College London
学者数:
7.9W
论文数: 6.2W
被引数: 15.7W
U
university of barcelona
学者数:
6.1W
论文数: 4.5W
被引数: 74
U
University of the Basque Country
学者数:
239
论文数: 133
被引数: 0
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