The Reactome Knowledgebase 2026

doi:10.1093/nar/gkaf1223

2025-11-01

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DOI：10.1093/nar/gkaf1223

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Reactome知识库（https://reactome.org）是一个免费访问、专家整理、开源和开放数据的资源，用于详细描述人类生物学。它涵盖了正常生理学以及疾病机制，包括遗传变异和药物作用的影响。Reactome的内容持续扩展和修订，目前通过自动化工作流程监控撤回出版物以维护数据完整性。为满足日益增长的用户需求，Reactome推出了一个基于Angular的重新设计的界面，具有增强的可访问性、模块化架构和可视化工具层级：ReacFoam用于全局通路概览，增强的高层示意图便于直观导航，以及重新设计的实体级别视图（ELVs），其中包含化学结构、动画蛋白模型和一个新的比较模式，用于对比正常和疾病状态。新的分析工具支持多组学集成和可定制的可视化。近期创新包括React-to-me聊天机器人用于自然语言交互、社区驱动的教程和一个开放的Figma图标库。Reactome的可持续性和符合FAIR数据原则最近获得了CoreTrustSeal认证及其作为全球核心生物数据资源和ELIXIR资源的指定，进一步巩固了其作为受信任的全球知识库的地位。

期刊

Nucleic Acids Research

IF:

13.1

论文数:

3.6W

被引数:

29.0W

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European Bioinformatics Institute

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