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The Spindle Assembly Checkpoint
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DOI：10.1016/j.cub.2012.10.006.png)
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摘要
En 中文
During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint network, which in turn blocks cell cycle progression. Once all kinetochores become stably attached to the spindle, the checkpoint is inactivated, which alleviates the cell cycle block and thus allows chromosome segregation and cell division to proceed. Here we review recent progress in our understanding of how the checkpoint signal is generated, how it blocks cell cycle progression and how it is extinguished.
Keyword:
ANAPHASE-PROMOTING COMPLEX
VERTEBRATE SOMATIC-CELLS
MITOTIC CHECKPOINT
KINETOCHORE LOCALIZATION
CHROMOSOME SEGREGATION
CENTROMERIC COHESION
MICROTUBULE-BINDING
STRUCTURAL-ANALYSIS
MAD2 ACTIVATION
KINASE-ACTIVITY
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对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
7.5
论文数:
2.2W
被引数:
7.8W
机构
引用论文
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