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TransBorrow: genome-guided transcriptome assembly by borrowing assemblies from different assemblers
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DOI：10.1101/gr.257766.119.png)
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摘要
En 中文
RNA-seq technology is widely used in various transcriptomic studies and provides great opportunities to reveal the complex structures of transcriptomes. To effectively analyze RNA-seq data, we introduce a novel transcriptome assembler, TransBorrow, which borrows the assemblies from different assemblers to search for reliable subsequences by building a colored graph from those borrowed assemblies. Then, by seeding reliable subsequences, a newly designed path extension strategy accurately searches for a transcript-representing path cover over each splicing graph. TransBorrow was tested on both simulated and real data sets and showed great superiority over all the compared leading assemblers.
Keyword:
RNA-SEQ DATA
ISOFORM DISCOVERY
SPLICE JUNCTIONS
QUANTIFICATION
RECONSTRUCTION
ALIGNMENT
REVEALS
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期刊
IF:
5.5
论文数:
5.6K
被引数:
4.3W
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引用论文
Transcriptome assembly from long-read RNA-seq alignments with StringTie2用StringTie2从长读rna-seq比对进行转录组组装.png)
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