Trips-Viz: a transcriptome browser for exploring Ribo-Seq data

doi:10.1093/nar/gky842

2018-09-20

Stephen J. Kiniry

Patrick B. F. O’Connor

Audrey M. Michel

Pavel V. Baranov *

DOI：10.1093/nar/gky842

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摘要

En 中文

Ribosome profiling (Ribo-Seq) is a technique that allows for the isolation and sequencing of mRNA fragments protected from nuclease digestion by actively translating ribosomes. Mapping these ribosome footprints to a genome or transcriptome generates quantitative information on translated regions. To provide access to publicly available ribosome profiling data in the context of transcriptomes we developed Trips-Viz (transcriptome-wide information on protein synthesis-visualized). Trips-Viz provides a large range of graphical tools for exploring global properties of translatomes and of individual transcripts. It enables analysis of aligned footprints to evaluate datasets quality, differential gene expression detection, visual identification of upstream ORFs and alternative proteoforms. Trips-Viz is available at https://trips.ucc.ie.

Keyword:

TRANSLATION

ALIGNMENT

PLATFORM

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Nucleic Acids Research

IF:

13.1

论文数:

3.6W

被引数:

29.0W

机构

University College Cork

学者数:

1.5W

论文数: 1.3W

被引数: 1.7W

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