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Trisubstituted triumph
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DOI：10.1038/s41557-022-00959-4.png)
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摘要
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Trisubstituted macrocyclic alkenes are prominent moieties in natural products, and although ring-closing metathesis reactions can be used to access such targets, the yields are typically suboptimal and the stereochemical outcome is unpredictable. Now, a methodology has been developed that tackles both of these challenges.
Keyword:
METATHESIS
期刊
IF:
20.2
论文数:
4.4K
被引数:
4.8W
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The exploration of macrocycles for drug discovery - an underexploited structural class用于药物发现的大环的探索-未充分利用的结构类别
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E- and Z-trisubstituted macrocyclic alkenes for natural product synthesis and skeletal editing.png)
NATURE CHEMISTRY
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NATURE CHEMISTRYIF20.2
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