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Umpolung Strategy for Ynamide Difunctionalization
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DOI：10.1002/asia.202500995.png)
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摘要
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Tetrasubstituted enamides, a subclass of tetrasubstituted olefins, are valuable structural motifs found in conjugated materials and biologically active molecules. Among various synthetic approaches, the difunctionalization of electron-rich ynamides offers a concise and atom-economical route to access these frameworks. Due to their intrinsic electronic polarization, ynamides undergo highly regioselective additions with nucleophiles preferentially attacking the alpha-carbon, while electrophiles target the beta-carbon. Although this conventional paradigm is effective, it is restricted to predictable reactivity patterns. Umpolung reactivity, which reverses the native polarity of reactive centers, offers a powerful solution by enabling new bond-forming patterns and expanding access to otherwise challenging molecular architectures. This review highlights recent advances in ynamide difunctionalization using umpolung strategies.
Keyword:
difunctionalization
enamide
tetrasubstituted alkene
umpolung
ynamide
期刊
C
IF:
3.3
论文数:
8.2K
被引数:
1.7W
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