Waveguide-based microscope slide for label-free high-resolution imaging

doi:10.1063/5.0225792

2024-08-05

PRE

DOI：10.1063/5.0225792

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摘要

En 中文

Waveguide-based total internal reflection fluorescence microscopy has been widely adopted due to its excellent signal-to-noise ratio over a large field of view. However, with the increasing demand for label-free imaging, waveguide-based evanescent light scattering microscopy (ESM) has also garnered significant attention. Here, we present a low-cost waveguide-based microscope slide that offers easier integration with conventional optical microscopy. This microscope slide uses an incoherent light source coupled to a lithium tantalate (LT) planar waveguide to generate an evanescent light that illuminates samples located within a few hundred nanometers of the waveguide surface. We perform its application for imaging chromium nanoholes and polystyrene nanospheres, demonstrating its label-free, high-resolution, high-contrast imaging performance. LT waveguide microscope slides provide a simple and effective solution for ESM.

Keyword:

SINGLE

期刊

Applied Physics Letters

IF:

3.6

论文数:

10.4W

被引数:

17.8W

机构

southeast university - china

学者数:

5.3W

论文数: 4.9W

被引数: 57

Nanjing Normal University

学者数:

1.7W

论文数: 1.3W

被引数: 1.9W

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