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A food-derived intervention: black garlic polysaccharides alleviate slow transit constipation with multifaceted improvements in gastrointestinal function and microbiota
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DOI：10.1007/s13197-026-06753-1.png)
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Abstract
En 中文
This study evaluated the therapeutic effects of black garlic polysaccharides (BGPs) on slow transit constipation (STC)-like dysfunction in mice and compared their response profile with that of mosapride. A mouse model of STC-like dysfunction was established using a composite induction protocol. Mice were treated with mosapride or different doses of BGPs for 7 days. Body weight, intestinal transit rate, colonic water content, and fecal water content were evaluated. Colonic histopathology was assessed by hematoxylin and eosin (H&E) staining. c-Kit immunohistochemistry was examined in the myenteric region of the colonic muscularis, and gut microbiota composition was profiled by 16 S rRNA sequencing. Both BGPs and mosapride improved key constipation-related functional outcomes, including intestinal motility and hydration-related indices. BGPs were also associated with improved colonic histopathology, increased c-Kit immunostaining and treatment-associated changes in the genus Colidextribacter, which was reduced in the Model group. These effects were more evident in the BGP-M and BGP-H groups. BGPs alleviated constipation-like dysfunction in mice and showed a response profile distinct from that of mosapride. Treatment with BGPs was also associated with histopathological, c-Kit-related, and microbiota-related changes. These findings support further investigation of BGPs as a food-derived candidate for constipation management.
Keywords:
Black garlic polysaccharides
Slow transit constipation
Gastrointestinal motility
Gut microbiota
Functional food
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3.3
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2.5W
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