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A masked generative graph representation learning framework empowering precise spatial domain identification
DOI:10.1093/bioinformatics/btag333.png)
Abstract
En 中文
Spatial transcriptomics (ST) enables the measurement of gene expression while preserving the spatial context of tissues. However, the sparsity of ST data leads to poor usage of gene expression and spatial information, resulting in the embeddings that are not well represented and challenging for downstream analyses.
Keywords:
Spatial transcriptomics
Gene expression
Graph representation learning
Spatial domain identification
Data sparsity
Journal
IF:
5.4
Papers:
1.3K
Citations:
17.9W
Organization
Cited Papers
A multi-view graph convolutional network framework based on adaptive adjacency matrix and multi-strategy fusion mechanism for identifying spatial domains
BIOINFORMATICS
IF5.4
In Situ Transcription Profiling of Single Cells Reveals Spatial Organization of Cells in the Mouse Hippocampus
NEURON
IF15
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
NATURE BIOTECHNOLOGY
IF41.7
Spatially informed clustering, integration, and deconvolution of spatial transcriptomics with GraphST
NATURE COMMUNICATIONS
IF15.7
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays
Cell
IF0

