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Abnormalities of the distal terminal ileum in people with cystic fibrosis assessed using magnetic resonance imaging
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DOI：10.1016/j.jcf.2026.07.009.png)
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Abstract
En 中文
• New MRI methods to measure the diameter of the distal terminal ileum (TI). • Normative values in healthy volunteers (HVs) determined. • 65% of people with cystic fibrosis (pwCF) showed faecalised material in the distal TI. • Mean cross-sectional area of the TI was threefold larger in pwCF than in HVs, likely reflecting increased chyme viscosity.
Keywords:
Cystic fibrosis
Gastrointestinal tract
Morphology
CF
Cystic fibrosis
CFTR
Cystic fibrosis transmembrane conductance regulator
CoV
Coefficient of Variation
CT
Computed tomography
DIOS
Distal intestinal obstruction syndrome
FEV1
Forced expiratory volume in 1 second
GI
Gastrointestinal
GRAMPUS-CF
Gut research advancing a mechanistic and Personalised understanding of symptoms in cystic fibrosis
HVs
Healthy volunteers
IBS-D
Irritable bowel syndrome with diarrohea
MRI
Magnetic resonance imaging
PERT
Pancreatic enzyme replacement therapy
pwCF
People with cystic fibrosis
TI
Terminal ileum
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