.png){kind=icon}
Return
Adding New Chemistries to the Genetic Code
.png){kind=icon}
PRE
AI
DOI：10.1146/annurev.biochem.052308.105824.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
The development of new orthogonal aminoacyl-tRNA synthetase/tRNA pairs has led to the addition of approximately 70 unnatural amino acids (UAAs) to the genetic codes of Escherichia coli, yeast, and mammalian cells. These UAAs represent a wide range of structures and functions not found in the canonical 20 amino acids and thus provide new opportunities to generate proteins with enhanced or novel properties and probes of protein structure and function.
Keywords:
aminoacyl-tRNA synthetase
protein engineering
protein evolution
translation
Journal
IF:
20.5
Papers:
2.2K
Citations:
2.1W
Organization
Cited Papers
ShareSaveShareSaveShareSaveControl of protein phosphorylation with a genetically encoded photocaged amino acid.png)
NATURE CHEMICAL BIOLOGY
NATURE CHEMICAL BIOLOGYIF13.7
PREAI
ShareSaveShareSave
A non-natural amino acid for efficient incorporation into proteins as a sensitive fluorescent probeFEBS LETTERS
FEBS LETTERSIF3
PREAI
ShareSave
View more