Antiviral defenses are diminished at birth in cystic fibrosis pig airways

Jennifer A. Bartlett

doi:10.1016/j.jcf.2026.07.1985

Antiviral defenses are diminished at birth in cystic fibrosis pig airways

2026-08-02

0

PRE

AI

J

Jennifer A. Bartlett

M

Miguel Ortiz

L

Linda S. Powers

C

Christine Wohlford-Lenane

C

Camilla E. Hippee

L

Laura Marquez Loza

J

Justin W. Kaufman

B

Brajesh K. Singh

D

Daniel I. Sands

E

Eric D. Huntemann

A

Ashley L. Cooney

M

Mark P. Rogan

C

Clifford C. Taggart

D

David K. Meyerholz

P

Paul B. McCray *

DOI：10.1016/j.jcf.2026.07.1985

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Abstract

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• The CF pig model allows us to study the antiviral responses of CF lungs in very early life, prior to the onset of inflammation and lung disease. • Airway epithelia from newborn CF and non-CF pigs respond similarly to influenza infection. • However, newborn CF pigs show greater viral loads and immune responses than non-CF pigs when challenged with influenza in vivo. • Impairment of antiviral responses is present at birth in CF pigs.

Antiviral defenses are diminished at birth in cystic fibrosis pig airways

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