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Broad-spectrum anti-influenza activity of the NMPA-approved drug Pamiparib is uncovered by virtual docking to the evolutionarily conserved domain of IAV-M2 protein

delete2025-12-05
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PRE
AI
M
Min Chen
D
Dandan Lu
W
W. William Chen
Z
Zhen Yang
L
Liang Xue *
P
Pengcheng Wei *
L
Liu, Kunpeng *
DOI：10.1016/j.bmc.2025.118518delete
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Abstract

Abstract

En 中文
• This study designs drugs targeting evolutionarily conserved regions of viral proteins, which can overcome the disadvantage that drugs screened by traditional methods are susceptible to viral protein mutations. • Drugs designed by targeting evolutionarily conserved domains of viral proteins shared by different strains and subgroups have broad-spectrum antiviral effects. • It provides a feasible method for screening broad-spectrum antiviral drugs.

Journal

B
Bioorganic and Medicinal Chemistry
IF:
3
Papers:
1.7W
Citations:
2.7W

Organization

G
guangxi university
Scholars:
3.2W
Papers: 1.8W
Citations: 25
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