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Building robust functionality in synthetic circuits using engineered feedback regulation
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DOI：10.1016/j.copbio.2013.02.025.png)
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Abstract
En 中文
The ability to engineer novel functionality within cells, to quantitatively control cellular circuits, and to manipulate the behaviors of populations, has many important applications in biotechnology and biomedicine. These applications are only beginning to be explored. In this review, we advocate the use of feedback control as an essential strategy for the engineering of robust homeostatic control of biological circuits and cellular populations. We also describe recent works where feedback control, implemented in silico or with biological components, was successfully employed for this purpose.
Keywords:
YEAST SACCHAROMYCES-CEREVISIAE
PROGRAMMED POPULATION-CONTROL
CELL-CELL COMMUNICATION
ESCHERICHIA-COLI
GENE-EXPRESSION
PERFECT ADAPTATION
CHEMOTAXIS
DESIGN
SYSTEM
NETWORK
Journal
IF:
7
Papers:
5.0K
Citations:
1.9W
Organization
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