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Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates

delete2019-10-25
delete5
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OA
AI
M
Mara Tomassetti *
G
Gabriele Lupidi
P
Pamela Piermattei
F
Federico Vittorio Rossi
S
Samuele Lillini
G
Gianluca Bianchini
A
Andrea Aramini
M
Marco A. Ciufolini
E
Enrico Marcantoni *
DOI：10.3390/molecules24213846delete
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Abstract

Abstract

En 中文
A catalyst-free heterocyclization reaction of alpha-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.
Keywords:
alpha-chloroglycinates
5-acylamino-1
3-thiazoles
Hantzsch reaction
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Molecules cover
Molecules
IF:
4.6
Papers:
6.4W
Citations:
23.7W

Organization

D
dompe
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200
Papers: 138
Citations: 0
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University of Camerino
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Papers: 3.4K
Citations: 2
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University of British Columbia
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Papers: 6.1W
Citations: 8.6W
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