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Centaurea virgata Lam. Instigates EtOH-Induced Gastric Toxicity/Ulcer In Vivo: Role of SOD/MDA, Bax/HSP 70, and TNF-α/IL-10
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DOI：10.1155/jfbc/5544037.png)
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Abstract
En 中文
Centaurea virgata is broadly used as a traditional food and medicine across the globe for numerous health purposes. Although the species is reported to have antioxidant and anti-inflammatory activities, literature data on its gastroprotective effects are scarce. Due to numerous shortcomings of conventional anti-ulcer drugs, natural products gained renewed interest as a safer alternative. This study aimed to investigate the acute toxicity and gastroprotective effects of the aerial part extracts of Centaurea virgata (APCV) on ethanol-induced gastric ulcers in Sprague–Dawley rats. Rats were divided into 5 groups: normal control, ulcer control (saline + EtOH), reference (lansoprazole + EtOH), APCV 100 mg/kg + EtOH, and APCV 200 mg/kg + EtOH. APCV 100 or 200 mg/kg, administered orally 1 h before the ethanol-induced ulcer procedure delivery, increased the protective index % (26.82% and 31.40%, respectively). The histopathological results (using H&E and PAS) indicated preserved gastric defense barriers (restored mucus secretion and gastric pH) and tissue architecture as a result of APCV pretreatment. APCV intervention (100 and 200 mg/kg) increased superoxide dismutase by 24.33% and 62.14%; catalase by 59.07% and 90.37%; and upregulated IL-10 by 24.40% and 79.52%, while significantly (p < 0.01) lowering MDA by 25.97% and 38.77%, as well as significantly (p < 0.001) downregulated IL-6 by 14.67% and 33.08% and TNF-α by 37.82% and 47.59%, respectively, compared to ulcer controls. It could also be noted that inhibited apoptosis (inhibited pro-apoptotic Bax and increased HSP 70 appearances in gastric tissues) occurred in gastric tissues pretreated with APCV. Taken together, APCV exhibited a gastroprotective potential against gastric ulcers, which is attributed to its attenuation effects on oxidative stress, inflammatory, and apoptotic pathways.
Keywords:
antioxidant
apoptosis
Centaurea virgata Lam.
gastric ulcer
inflammation
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