CFTR modulator therapy reshapes airway inflammation in cystic fibrosis: Insights from proteomics and machine learning

Filip Årman

doi:10.1016/j.jcf.2026.05.002

CFTR modulator therapy reshapes airway inflammation in cystic fibrosis: Insights from proteomics and machine learning

2026-07-14

0

OA

AI

F

Filip Årman

S

Stefanie Diemer

L

Lotta Happonen

L

Lisa I. Påhlman *

DOI：10.1016/j.jcf.2026.05.002

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Abstract

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• ETI improves outcomes in CF, but airway inflammatory biology is incompletely defined. • Longitudinal DIA proteomics reveals airway molecular effects of ETI. • ETI reduces neutrophil-driven inflammation in CF sputum proteomes. • Machine learning identifies sputum proteins linked to ETI response.

Keywords:

Cystic fibrosis

Elexacaftor/Tezacaftor/Ivacaftor

CFTR modulator therapy

Airway inflammation

Lung function

Proteome

Cytokines

Machine learning

CFTR modulator therapy reshapes airway inflammation in cystic fibrosis: Insights from proteomics and machine learning

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