Comparative liquid chromatography–electrospray ionization–tandem mass spectrometry profiling and bioactivity evaluation of Ebenus macrophylla Jaub. & Spach leaf, stalk and root extracts: an in vitro and in silico approach

Tuğrul Çağrı Akman

doi:10.1002/jsfa.70362

Comparative liquid chromatography–electrospray ionization–tandem mass spectrometry profiling and bioactivity evaluation of Ebenus macrophylla Jaub. & Spach leaf, stalk and root extracts: an in vitro and in silico approach

2025-12-06

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Tuğrul Çağrı Akman *

S

Samed Şimşek

Z

Zeynep Akşit

H

Hüseyin Akşit

A

Ali Aydın

Ş

Şevki Adem

A

Ali Rıza Tüfekçi

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İlyas Yıldız

DOI：10.1002/jsfa.70362

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Abstract

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Ebenus macrophylla Jaub. & Spach (EM), an endemic Turkish plant, is a rich source of bioactive compounds with potential therapeutic applications. This study aimed to analyze the phytochemistry of its leaf, stalk, and root extracts and evaluate their antioxidant, antimicrobial, enzyme inhibitory, and antiproliferative effects.

Keywords:

Ebenus macrophylla

antioxidant activity

antiproliferative activity

antimicrobial activity

enzyme inhibition

molecular docking

Comparative liquid chromatography–electrospray ionization–tandem mass spectrometry profiling and bioactivity evaluation of Ebenus macrophylla Jaub. & Spach leaf, stalk and root extracts: an in vitro and in silico approach

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