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Condition-dependent amorphous protein agglomerates control cytoplasmic rheology
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DOI：10.1016/j.molcel.2026.03.018.png)
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Abstract
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• Cytoplasmic diffusion of 40-nm particles varies 3-fold across growth conditions in E. coli • Diffusion inversely correlates with amino acid metabolic (COG-E) protein abundance • COG-E proteins form agglomerates that increase cytoplasmic elasticity • Protein hydrophobicity and compactness predict condition-dependent crowding effects
Keywords:
cytoplasm
protein agglomeration
amino acid metabolism
single-particle tracking
intracellular diffusion
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