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Deciphering bacterial epigenomes using modern sequencing technologies
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DOI：10.1038/s41576-018-0081-3.png)
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Abstract
En 中文
Prokaryotic DNA contains three types of methylation: N6-methyladenine, N4-methylcytosine and 5-methylcytosine. The lack of tools to analyse the frequency and distribution of methylated residues in bacterial genomes has prevented a full understanding of their functions. Now, advances in DNA sequencing technology, including single-molecule, real-time sequencing and nanopore-based sequencing, have provided new opportunities for systematic detection of all three forms of methylated DNA at a genome-wide scale and offer unprecedented opportunities for achieving a more complete understanding of bacterial epigenomes. Indeed, as the number of mapped bacterial methylomes approaches 2,000, increasing evidence supports roles for methylation in regulation of gene expression, virulence and pathogen-host interactions.
Keywords:
RESTRICTION-MODIFICATION SYSTEMS
SITE-SPECIFIC METHYLATION
DNA ADENINE METHYLATION
SINGLE-MOLECULE
PHASE VARIATION
DAM METHYLATION
NEISSERIA-MENINGITIDIS
ESCHERICHIA-COLI
GENE-EXPRESSION
MODIFICATION ENZYMES
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