Deep learning-powered enzyme efficiency boosting with evolutionary information

Jaie Woodard

doi:10.1016/j.scib.2024.03.034

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Deep learning-powered enzyme efficiency boosting with evolutionary information

2024-05-01

PRE

Jaie Woodard *

Xiaoqiang Huang *

DOI：10.1016/j.scib.2024.03.034

Original

Original request for help

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Abstract

Journal

Science Bulletin

IF:

21.1

Papers:

5.2K

Citations:

2.2W

Organization

University of Michigan

Scholars:

6.4W

Papers: 5.3W

Citations: 124

university of michigan system

Scholars:

9.1W

Papers: 8.6W

Citations: 133

Cited Papers

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Machine-learning-guided directed evolution for protein engineering

NATURE METHODS

IF32.1

2019-07-15

657

OAAI

Yang, Kevin K.; Wu, Zachary; Arnold, Frances H.

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Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign

JOURNAL OF BIOLOGICAL CHEMISTRY

IF3.9

2023-08-01

OAAI

Huang, Xiaoqiang; Sun, Yudong; Osawa, Yoichi; Chen, Y. Eugene; Zhang, Haoming

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Rhabdopleuran hemichordates: new fossil forms and review

Proceedings of the Geologists' Association

IF0

1995-01-01

PREAI

A.J. Chapman; P.N. Durman; R.B. Rickards

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Predicting the clinical impact of human mutation with deep neural networks

NATURE GENETICS

IF31.8

2018-07-23

298

OAAI

Sundaram, Laksshman; Gao, Hong; Padigepati, Samskruthi Reddy; McRae, Jeremy F.; Li, Yanjun; Kosmicki, Jack A.; Fritzilas, Nondas; Hakenberg, Jorg; Dutta, Anindita; Shon, John; Xu, Jinbo; Batzloglou, Serafim; Li, Xiaolin; Farh, Kyle Kai-How

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Flexible shaping: How learning in small steps helps

Cognition

IF0

2009-03-01

OAAI

Kai A. Krueger; Peter Dayan

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Unified rational protein engineering with sequence-based deep representation learning

NATURE METHODS

IF32.1

2019-10-21

645

OAAI

Alley, Ethan C.; Khimulya, Grigory; Biswas, Surojit; AlQuraishi, Mohammed; Church, George M.

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Diode laser-based nonlinear degenerate four-wave mixing analytical spectrometry

Spectrochimica Acta Part B: Atomic Spectroscopy

IF0

1994-10-01

PREAI

Sandrine Berniolles; Zhiqiang Wu; William G. Tong

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Low-N protein engineering with data-efficient deep learning

NATURE METHODS

IF32.1

2021-04-07

223

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Biswas, Surojit; Khimulya, Grigory; Alley, Ethan C.; Esvelt, Kevin M.; Church, George M.

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A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells

NATURE MEDICINE

IF50

2018-08-06

595

OAAI

Vakulskas, Christopher A.; Dever, Daniel P.; Rettig, Garrett R.; Turk, Rolf; Jacobi, Ashley M.; Collingwood, Michael A.; Bode, Nicole M.; McNeill, Matthew S.; Yan, Shuqi; Camarena, Joab; Lee, Ciaran M.; Parka, So Hyun; Wiebking, Volker; Bak, Rasmus O.; Gomez-Ospina, Natalia; Pavel-Dinu, Mara; Sun, Wenchao; Bao, Gang; Porteus, Matthew H.; Behlke, Mark A.

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