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Design, synthesis and anti-necroptosis evaluation of RIPK1 inhibitors derived from sunitinib
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DOI：10.1016/j.ejmech.2026.118925.png)
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Abstract
En 中文
• Compound 5e identified as potent RIPK1 inhibitor • 5e dose-dependently inhibited phosphorylation of RIPK1, RIPK3 and MLKL • 5e preserved mitochondrial and lysosomal integrity in L929 necroptosis model • 5e improved survival (83%) and attenuated multi-organ damage in SIRS mice
Keywords:
RIPK1 inhibitor
necroptosis
mitochondrial integrity
lysosomal integrity
SIRS mice
Journal
IF:
5.9
Papers:
1.7W
Citations:
6.0W
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Cited Papers