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Design, synthesis, and biological evaluation of 2-amino-1,3,4-thiadiazoles as new potential EGFR inhibitors for treatment of cancer
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DOI：10.1016/j.bmc.2025.118527.png)
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Abstract
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• The visible light mediated organophotocatalytic synthesis of 2-amino-1, 3,4-thiadiazoles as potent EGFR inhibitors. • Induced fit docking-molecular dynamics (IFD-MD) simulations driven SAR to identify lead EGFR inhibitor. • The cell cycle analysis and apoptotic effect of lead molecule in HepG2 cells. • Western blot analysis underscores the potential of the lead molecule as a targeted modulator of EGFR signalling.
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B
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3
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1.7W
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2.7W
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