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Design, synthesis, and biological evaluation of a focused pyrrolo- and pyrido-quinazolinone natural products-templated library for anti-fungal and anthelmintic activities
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DOI：10.1016/j.bmc.2025.118517.png)
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Abstract
En 中文
• Synthesis of a focused pyrrolo and pyrido quinazolinone natural products (QNPs)-templated library of 70 new compounds (experimental details along with structural characterization data is provided) via novel in-house chemistry. • QNPs structure-based library was screened against pathogenic fungi and parasitic helminths to identify the active leads (material and methods have been provided). • Three compounds have been identified as potent inhibitors of C. auris- adhesion, and two compounds (13 k, 14 h) were identified as active anthelmintic agents. That would serve as leads for further optimizations.
Journal
B
IF:
3
Papers:
1.7W
Citations:
2.7W
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Cited Papers