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Design, synthesis, and evaluation of indole-pyridine chalcone derivatives as novel HK2 inhibitors to modulate macrophage glycolysis and inflammation for IBD treatment
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DOI：10.1016/j.ejmech.2026.118922.png)
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Abstract
En 中文
• A series of novel indole-chalcone derivatives were designed and synthesized. • SPR and pull-down experiments confirmed that ZSW could directly bind to HK2. • ZSW significantly inhibits HK2 enzyme activity and LPS-induced inflammatory. • ZSW could modulate macrophage glycolysis and inflammation for IBD treatment.
Keywords:
indole-chalcone derivatives
HK2 inhibitors
macrophage glycolysis
inflammation
IBD treatment
Journal
IF:
5.9
Papers:
1.7W
Citations:
6.0W
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Cited Papers