Smartphone-Operated FRET Platform with Aggregation-Induced Emission MOFs and Spiky Carbon Nanospheres for Rapid Quantification of CA125 and HE4

Enhui Zhang

doi:10.1021/acssensors.6c00594

Design, synthesis and structure-activity relationship study of novel indole-pyrrole scaffold compounds targeting Nur77 in colorectal tumor cells

2026-05-05

0

PRE

AI

Q

Qi Zhao

J

Jingmei Liang

J

Jin Zhou

M

Meifeng Zeng

W

Wenbiao Zhang

Y

Yuan Cao

X

Xiaokun Zhang

X

Xiaohui Chen *

G

Guobin Xie *

Y

Ying Su *

Z

Zhiping Zeng *

DOI：10.1016/j.ejmech.2026.118927

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Abstract

En 中文

• 1: New SIM-C-PhCF3+Cl- derivatives are rationally designed and synthesized. • 2: Compound A6 displays the most potent anti-proliferative activity against colorectal tumor cells. • 3: Compound A6 binds Nur77 with high affinity (Kd = 0.40 ± 0.05 μM). • 4: Compound A6 exhibits anti-mitotic activity in a Nur77-dependent manner. • 5: The SIM-C-PhCF3+Cl- are essential for the enhanced inhibitory effects on cell proliferation and mitotic arrest.

Keywords:

Nur77

colorectal tumor cells

anti-proliferative activity

mitotic arrest

structure-activity relationship

Design, synthesis and structure-activity relationship study of novel indole-pyrrole scaffold compounds targeting Nur77 in colorectal tumor cells

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