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Development of Daunorubicin-loaded Bovine Serum Albumin Nanoparticles – Preparation, Characterisation, Optimization of Production Process, Investigation of In Vitro and In Vivo Toxicity and Activity
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DOI：10.1016/j.colsurfb.2026.115623.png)
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Abstract
En 中文
• Albumin-based nanoparticles containing daunorubicin were prepared using the desolvation method • The parameters of the desolvation process were optimized, and a standardized protocol was developed for the use of daunorubicin-containing BSA nanoparticles, enabling their use in future anti-cancer researc • The cytotoxic effects of the prepared nanoparticles were tested on four different cancer cell lines • In vivo toxicity revealed that the daunorubicin containing BSA nanoparticles exhibited reduced toxicity compared with free daunorubicin
Keywords:
daunorubicin
Drug delivery system
Albumin nanoparticles
drug release
in vitro investigation
in vivo toxicity,
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