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Directed evolution approaches for optogenetic tool development
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DOI：10.1042/BST20210700.png)
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Abstract
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Photoswitchable proteins enable specific molecular events occurring in complex biological settings to be probed in a rapid and reversible fashion. Recent progress in the development of photoswitchable proteins as components of optogenetic tools has been greatly facilitated by directed evolution approaches in vitro, in bacteria, or in yeast. We review these developments and suggest future directions for this rapidly advancing field.
Keywords:
FLUORESCENT PROTEINS
TRANSCRIPTION FACTOR
OPTICAL CONTROL
LIGHT
SYSTEM
PHOTORECEPTORS
LOV
CYANOBACTERIOCHROMES
LOCALIZATION
RESOLUTION
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