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Discovery and characterization of a high-affinity G-quadruplex binding peptide via mRNA display

delete2025-12-27
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PRE
AI
N
N Ida
Y
Yoshimasa Kawaguchi
S
Shiroh Futaki
M
Miki Imanishi *
DOI：10.1016/j.bmc.2025.118543delete
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Abstract

Abstract

En 中文
• A Novel G-quadruplex (G4)-specific peptide, LP7, was identified using mRNA-display screening. • Basic and aromatic amino acid residues in LP7 contribute to G4 binding. • Dimerization of LP7 resulted in a 70-fold increase in binding affinity to hTERC G4 RNA (rG4), achieving a Kd of 7 nM. • LP7 was shown to inhibit reverse transcription in a G4-dependent manner.

Journal

B
Bioorganic and Medicinal Chemistry
IF:
3
Papers:
1.7W
Citations:
2.7W

Organization

K
Kyoto University
Scholars:
5.1W
Papers: 4.6W
Citations: 6.1W
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