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Discovery of novel hybrids of coumarin and quinoline as potential anti-Alzheimer's disease agent

delete2025-11-26
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PRE
AI
S
Shun Li
X
Xinrui Li
S
Shuanglong Li
D
Daoyuan Chen *
C
Chunli Xia *
DOI：10.1016/j.bmc.2025.118499delete
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Abstract

Abstract

En 中文
• 24 coumarin-quinoline hybrids were designed as multi-target-directed ligands for Alzheimer's multifaceted nature. • Lead compound B8 inhibited key targets (Aβ aggregation, cholinesterase, BACE1) and crossed the BBB. • B8 improved cognition in AD mice by reducing oxidative stress, inflammation, and Aβ deposition. • The hybrid strategy and compound B8 demonstrate significant promise for novel AD therapy development.

Journal

B
Bioorganic and Medicinal Chemistry
IF:
3
Papers:
1.7W
Citations:
2.7W

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