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Discovery of Preclinical Candidate CG-0988, a Novel Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease Inhibitor Bearing Spirooxindole

delete2026-04-30
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PRE
AI
X
Xiubo Tang *
K
Kai Hou
X
Xiaowu Chen
W
Wenyuan Fan
H
Hao Wu
J
Jia Meng
C
Changliang Lu
G
Gong-Xin He
DOI：10.1016/j.ejmech.2026.118889delete
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Abstract

Abstract

En 中文
• Discovery of SARS-CoV2 3CLpro inhibitors bearing spirooxindole • CG-0988 demonstrates potent in vitro antiviral activity and metabolic stability • CG-0988 exhibits excellent pharmacokinetics profiles in rats and dogs
Keywords:
3CLpro inhibitor
spirooxindole
SARS-CoV-2
antiviral activity
pharmacokinetics

Journal

European Journal of Medicinal Chemistry cover
European Journal of Medicinal Chemistry
IF:
5.9
Papers:
1.7W
Citations:
6.0W

Organization

No organization information available
Cited Papers

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Citing Papers

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