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Discovery of thiosemicarbazone derivatives as promising SARS-CoV-2 Mpro inhibitors by spectroscopy and microscale thermophoresis
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DOI：10.1016/j.bmc.2025.118501.png)
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Abstract
En 中文
• For the first time, four thiosemicarbazone derivatives were synthesized and shown to bind specifically to Mpro with inhibitory effects. • Results indicate that thiosemicarbazone derivatives 1e is the strongest inhibitor for Mpro with IC50 = 5.97 μM in this work. • Results of microscale thermophoresis indicate that the Kd between 1e and Mpro was 4.21 μM. • Spectroscopic studies indicated that 1e bind to Mpro mainly through hydrogen bonding and van der Waals forces.
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B
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3
Papers:
1.7W
Citations:
2.7W
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Cited Papers