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Editing without Breaking: Sustained Gene Control via Epigenetic Rewriting
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DOI：10.1016/j.cobme.2026.100663.png)
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Abstract
En 中文
In the last 25 years, epigenetics has become a mature independent discipline, rooted in fundamental research in developmental biology and advancing towards clinical tools such as predictive epigenetic biomarkers and epigenetic drugs. Despite FDA-approval, such epi-drugs suffer from genome-wide effects. Epigenetic editing, rewriting chromatin biochemical marks in a gene-targeted fashion, has received academic and commercial interest.
Keywords:
epigenetic editing
gene control
chromatin marks
epigenetic biomarkers
epi-drugs
Journal
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4.2
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103
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