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Effect of Olezarsen on Lipoprotein-Associated ApoC-III Levels in Patients with Familial Chylomicronemia Syndrome
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DOI：10.1016/j.atherosclerosis.2025.120462.png)
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Abstract
En 中文
• In FCS, olezarsen lowers apoC-III across all major lipoprotein pools. • The largest reductions were in apoC-III on total apoB and apoA-I particles. • Modest effects were observed on apoC-III bound to apoB-100 and Lp(a) • Lipoprotein-specific assays reveal mechanistic treatment insights with olezarsen. • Measuring apoC-III across lipoproteins may guide future studies in pancreatitis and CVD.
Keywords:
olezarsen
apoC-III
lipoproteins
FCS
pancreatitis
CVD
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