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Engineering Cell Surface Function with DNA Origami
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DOI：10.1002/adma.201703632.png)
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Abstract
En 中文
A specific and reversible method is reported to engineer cell-membrane function by embedding DNA-origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher-order DNA assemblies at the cell surface and programed cell-cell adhesion between homotypic and heterotypic cells via sequence-specific DNA hybridization. It is anticipated that integration of DNA-origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.
Keywords:
cell surface engineering
DNA nanotechnology
DNA origami
intercellular adhesion
membrane functionalization
Journal
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26.8
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3.5W
Citations:
47.0W
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Cited Papers
A biomimetic DNA-based channel for the ligand-controlled transport of charged molecular cargo across a biological membrane.png)
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