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Establishing the lowest penicillin concentration to prevent pharyngitis due to Streptococcus pyogenes using a human challenge model (CHIPS): a randomised, double-blind, placebo-controlled trial

delete2025-05-01
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OA
AI
T
Thel K. Hla
J
Joshua Osowicki
J
Julie Marsh
S
Sam Salman
M
Madhu Page‐Sharp
O
Okhee Yoo
K
Kristy Azzopardi
M
Michael Morici
K
Kevin T. Batty
R
Renae K. Barr
S
Stephanie Enkel
J
Joseph Kado
L
Lara Hatchuel
A
Alma Fulurija
J
James McCarthy
T
Thomas L Snelling
A
Andrew C. Steer
J
Jonathan R. Carapetis
L
Laurens Manning *
DOI:10.1016/j.lanmic.2024.101038delete
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Abstract

Abstract

En 中文
The in-vivo plasma concentration of penicillin needed to prevent Streptococcus pyogenes pharyngitis, recurrent acute rheumatic fever, and progressive rheumatic heart disease is not known. We used a human challenge model to assess the minimum penicillin concentration required to prevent streptococcal pharyngitis.
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Journal

Lancet Microbe cover
Lancet Microbe
IF:
20.4
Papers:
326
Citations:
5.8K

Organization

L
linear clinical research
Scholars:
105
Papers: 73
Citations: 1
U
University of Sydney
Scholars:
6.5W
Papers: 6.2W
Citations: 90
C
Curtin University
Scholars:
1.5W
Papers: 1.8W
Citations: 2.8W
T
telethon kids institute
Scholars:
55
Papers: 20
Citations: 1
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