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Exploring Diverse Chemotypes of Natural Polyenes as Promising Antimicrobial Candidates: Latest Progress and Limitations
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DOI：10.1016/j.ejmech.2026.118930.png)
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Abstract
En 中文
• This rise in antimicrobial-resistant pathogens has led to significant morbidity and mortality. • Natural products exhibit a remarkable variety of scaffolds, and their contributions have been crucial in drug discovery. • Polyenes are lipophilic or amphipathic compounds that readily permeate the membranes of pathogens, inhibiting their growth. • Polyene-based compounds such as amphotericin, nystatin, and natamycin are used to treat fungal diseases, with the lowest likelihood of developing resistance. • The natural origin of polyenes underscores the ongoing need to enhance antibiotic drug discovery efforts.
Keywords:
Natural products
Polyenes
Antimicrobial resistance
Drug discovery
Chemotypes
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5.9
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6.0W
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