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Fibronectin-guided migration of carcinoma collectives
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DOI：10.1038/ncomms14105.png)
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Abstract
En 中文
Functional interplay between tumour cells and their neoplastic extracellular matrix plays a decisive role in malignant progression of carcinomas. Here we provide a comprehensive data set of the human HNSCC-associated fibroblast matrisome. Although much attention has been paid to the deposit of collagen, we identify oncofetal fibronectin (FN) as a major and obligate component of the matrix assembled by stromal fibroblasts from head and neck squamous cell carcinomas (HNSCC). FN overexpression in tumours from 435 patients corresponds to an independent unfavourable prognostic indicator. We show that migration of carcinoma collectives on fibrillar FN-rich matrices is achieved through alpha v beta 6 and alpha 9 beta 1 engagement, rather than alpha 5 beta 1. Moreover, alpha v beta 6-driven migration occurs independently of latent TGF-beta activation and Smad-dependent signalling in tumour epithelial cells. These results provide insights into the adhesion-dependent events at the tumour-stroma interface that govern the collective mode of migration adopted by carcinoma cells to invade surrounding stroma in HNSCC.
Keywords:
ORAL SQUAMOUS-CELL
EXTRACELLULAR-MATRIX
EXTRA-DOMAIN
TGF-BETA
INTEGRIN
CANCER
ADHESION
PROTEIN
FIBROBLASTS
EXPRESSION
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